Melatonin is a hormone (N‑acetyl-5‑methoxytryptamine) produced especially at night in the pineal gland. Its secretion is stimulated by darkness and inhibited by light. Melatonin, an indole, is synthesized from tryptophan via serotonin. The suprachiasmatic nuclei (SCN) of the hypothalamus have melatonin receptors and melatonin may have a direct action on SCN to influence circadian (sleep) rhythms.
Adults: Spray 4-22 times daily under the tongue (4, 11, and 22 sprays provide approximately 1.5, 5, and 10 mg of melatonin, respectively) or as directed by your health-care practitioner. Sensitivity to melatonin is different from person to person. Take once a day, at or before bedtime.
For jet lag: Take once a day at bedtime after darkness has fallen, while travelling and at destination, until adaptation to the new daily pattern on occasional short-term use. For sleep restriction / altered sleep schedule, for delayed sleep phase disorder, and to restore sleep/wake cycle: Consult a health-care practitioner for use beyond 4 weeks or if symptoms persist for more than 4 weeks (chronic insomnia).
Each spray contains:
| Melatonin (N‑acetyl-5‑methoxytryptamine) | 440 mcg |